On Physical Disorder Based Hardware Security Primitives

With CMOS scaling extending transistors to nanometer regime, process variations from manufacturing impacts modern IC design. Fortunately, such variations have enabled an emerging hardware security primitive - Physically Unclonable Function. Physically Unclonable Functions (PUFs) are hardware primitives which utilize disorder from manufacturing variations for their core functionality. In contrast to insecure non-volatile key based roots-of-trust, PUFs promise a favorable feature - no attacker, not even the PUF manufacturer can clone the disorder and any attempt at invasive attack will upset that disorder. Despite a decade of research, certain practical problems impede the widespread adoption of PUFs. This dissertation addresses the important problems of (i) post-manufacturing testing, (ii) secure design and (iii) cost efficiency of PUFs. This is with the aim of making PUFs practical and also learning hardware design limitations of disorder based systems

On Improving Reliability of SRAM-Based Physically Unclonable Functions

Physically unclonable functions (PUFs) have been touted for their inherent resistance to invasive attacks and low cost in providing a hardware root of trust for various security applications. SRAM PUFs in particular are popular in industry for key/ID generation. Due to intrinsic process variations, SRAM cells, ideally, tend to have the same start-up behavior. SRAM PUFs exploit this start-up behavior. Unfortunately, not all SRAM cells exhibit reliable start-up behavior due to noise susceptibility. Hence, design enhancements are needed for improving reliability. Some of the proposed enhancements in literature include fuzzy extraction, error-correcting codes and voting mechanisms. All enhancements involve a trade-off between area/power/performance overhead and PUF reliability. This paper presents a design enhancement technique for reliability that improves upon previous solutions. We present simulation results to quantify improvement in SRAM PUF reliability and efficiency. The proposed technique is shown to generate a 128-bit key in ≤0.2 μ\u27\u3eμμ s at an area estimate of 4538 μ\u27\u3eμμ m 2\u27\u3e22 with error rate as low as 10−6\u27\u3e10−610−6 for intrinsic error probability of 15%

Population differentiation of Southern Indian male lineages correlates with agricultural expansions predating the caste system

Christina J. Adler, Alan Cooper, Clio S.I. Der Sarkissian and Wolfgang Haak are contributors to the Genographic ConsortiumPrevious studies that pooled Indian populations from a wide variety of geographical locations, have obtained contradictory conclusions about the processes of the establishment of the Varna caste system and its genetic impact on the origins and demographic histories of Indian populations. To further investigate these questions we took advantage that both Y chromosome and caste designation are paternally inherited, and genotyped 1,680 Y chromosomes representing 12 tribal and 19 non-tribal (caste) endogamous populations from the predominantly Dravidian-speaking Tamil Nadu state in the southernmost part of India. Tribes and castes were both characterized by an overwhelming proportion of putatively Indian autochthonous Y-chromosomal haplogroups (H-M69, F-M89, R1a1-M17, L1-M27, R2-M124, and C5-M356; 81% combined) with a shared genetic heritage dating back to the late Pleistocene (10–30 Kya), suggesting that more recent Holocene migrations from western Eurasia contributed, <20% of the male lineages. We found strong evidence for genetic structure, associated primarily with the current mode of subsistence. Coalescence analysis suggested that the social stratification was established 4–6 Kya and there was little admixture during the last 3 Kya, implying a minimal genetic impact of the Varna(caste) system from the historically-documented Brahmin migrations into the area. In contrast, the overall Y-chromosomal patterns, the time depth of population diversifications and the period of differentiation were best explained by the emergence of agricultural technology in South Asia. These results highlight the utility of detailed local genetic studies within India, without prior assumptions about the importance of Varna rank status for population grouping, to obtain new insights into the relative influences of past demographic events for the population structure of the whole of modern India.GaneshPrasad ArunKumar, David F. Soria-Hernanz, Valampuri John Kavitha, Varatharajan Santhakumari Arun, Adhikarla Syama, Kumaran Samy Ashokan, Kavandanpatti Thangaraj Gandhirajan, Koothapuli Vijayakumar, Muthuswamy Narayanan, Mariakuttikan Jayalakshmi, Janet S. Ziegle, Ajay K. Royyuru, Laxmi Parida, R. Spencer Wells, Colin Renfrew, Theodore G. Schurr, Chris Tyler Smith, Daniel E. Platt, Ramasamy Pitchappan, The Genographic Consortiu

On Improving Reliability of SRAM-Based Physically Unclonable Functions

Physically unclonable functions (PUFs) have been touted for their inherent resistance to invasive attacks and low cost in providing a hardware root of trust for various security applications. SRAM PUFs in particular are popular in industry for key/ID generation. Due to intrinsic process variations, SRAM cells, ideally, tend to have the same start-up behavior. SRAM PUFs exploit this start-up behavior. Unfortunately, not all SRAM cells exhibit reliable start-up behavior due to noise susceptibility. Hence, design enhancements are needed for improving reliability. Some of the proposed enhancements in literature include fuzzy extraction, error-correcting codes and voting mechanisms. All enhancements involve a trade-off between area/power/performance overhead and PUF reliability. This paper presents a design enhancement technique for reliability that improves upon previous solutions. We present simulation results to quantify improvement in SRAM PUF reliability and efficiency. The proposed technique is shown to generate a 128-bit key in ≤0.2 μ s at an area estimate of 4538 μ m 2 with error rate as low as 10 − 6 for intrinsic error probability of 15%

PRELIMINARY STUDY ON SALUBRIOUS EFFECT OF SYRINGIC ACID ON APOPTOSIS IN HUMAN LUNG CARCINOMA A549 CELLS AND INSILICO ANALYSIS THROUGH DOCKING STUDIES

ObjectiveTo analyse the anticancer activity of Syringic acid (SA) in lung carcinoma a549 cell line and investigate the mechanism of Bcl-2 inhibition by molecular docking analysis. MethodsThe antiproliferative activity of SA was analysed by MTT assay. Apoptosis ratio of SA treated cells was detected by Acridine orange/Ethidium bromide staining. Nuclear morphology of SA treated cells was assessed by propidium iodode staining method. Molecular docking was done with Bcl-2 by Autodock4v4 of human origin and the interaction was studies using pymol.Results Preliminary study with MTT assay revealed that SA had cytotoxicity toward A549 lung cancer cells with an IC50 of 30µM. AO/EB staining and PI staining confirms that there is a significant increase in the percentage of apoptotic cells and nuclei respectively of SA treated cells. Further, molecular docking analysis revealed SA inhibited Bcl-2 with a binding score of –6.54 Kcal forming three Hydrogen bonds.ConclusionThese findings suggest that Syringic acid has potential therapeutic benefit and promises to be a weapon against lung cancer

Low serum 25-hydroxy vitamin D levels are associated with aggressive breast cancer variants and poor prognostic factors in patients with breast carcinoma

ABSTRACT Objective: This study was conducted to assess the serum 25-hydroxy (OH) vitamin D levels in patients with breast cancer compared to healthy controls and to identify its association with aggressive breast cancer phenotypes. Materials and methods: Serum 25-OH vitamin D levels of 78 breast cancer patients and 78 matched healthy controls were estimated using ELISA. The cases and controls were matched with respect to age, menopausal status, parity, weight, height and co-morbidities. Prognostic factors like grade of tumour, hormone receptor status, HER2 neu status and lymphovascular invasion were compared with 25-OH vitamin D levels. Results: The mean serum 25-OH vitamin D levels of cases were significantly lower compared to the controls (22.33 ± 8.19 vs. 37.41 ± 12.9 ng/mL; p = 0.0001). Patients with higher grades of tumour, non-luminal types of breast cancer and breast cancers with estrogen receptor negativity had significantly lower serum 25-OH vitamin D levels than their opposing groups. Patients with excellent and good Nottingham's prognostic Index (NPI) had significantly higher serum 25-OH vitamin D levels than the moderate and poor NPI groups. Conclusion: Newly diagnosed breast cancer patients have significantly lower serum 25-OH vitamin D levels than healthy controls. Lower level of serum 25-OH vitamin D correlates with aggressive breast cancer phenotypes